Researchers from the Department of Chemistry, Marijana Pocrnić, Vladislav Tomišić, and Nives Galić, in collaboration with Ana Čikoš (Ruđer Bošković Institute) and Ana Budimir (University of Zagreb, Faculty of Pharmacy and Biochemistry) as well as Marta Hoelm and Anna Ignaczak from the University of Lodz, have published the scientific paper entitled Inclusion complexes of loratadine with β-cyclodextrin and its derivatives in solution. Integrated spectroscopic, thermodynamic and computational studies in the prestigious Journal of Molecular Liquids (I.F. = 5.3).
A detailed study of the influence of β-cyclodextrin (β-CD) and its hydroxyprolylated, randomly methylated, and alkylsulfonylated derivatives on the loratadine (LOR) apparent solubility are presented. It was found that cyclodextrins considerably increased the LOR solubility due to the formation of 1:1 and 1:2 (LOR:CD) complexes. The inclusion of LOR into the CD cavity was thoroughly investigated from the structural and thermodynamic aspects using mass spectrometry, isothermal titration calorimetry, 1D and 2D NMR spectroscopy, and molecular modeling. The obtained results serve as a good starting point for the preparation and characterization of the corresponding inclusion complexes in the solid state as new drug formulations with enhanced functionalities.
The published results are part of Marijana Pocrnić PhD thesis. The research was conducted within the Croatian Science Foundation project: Preparation, characterization and biocompatibility studies of novel drug/cyclodextrin and drug/dextrin-based nanosponge supramolecular complexes with enhanced functionality (IP-2022-10-6033).
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